For Stephanie Matsuba—artist, actress, and instructor at BURN Los Angeles—movement has never been just about fitness. In this deeply honest conversation, Stephanie sits down with Amy Cohen Epstein to reflect on her journey living with bipolar II disorder, the early physical and emotional signals she learned to suppress, and the long road toward diagnosis, self-understanding, and care. From navigating illness as a teenager to discovering the stabilizing power of routine, structure, and community, this episode explores how mental health, movement, and self-advocacy intersect—and why listening to your body matters at every stage of life.

I’ve been spending a lot of time lately looking into peptides and trying new ones myself. Specifically, the quieter peptides that support how the body actually works. The kind that don’t push or stimulate, but instead help systems communicate better, adapt more gracefully, and recover more efficiently. Those are the ones that really hold my attention, especially when the conversation is about aging well, not fighting age, but supporting the body as it changes.

After cancer treatment ends, many survivors are told to celebrate and move on — but the emotional aftermath is often far more complicated. In this episode of The SEAM Podcast, Amy Cohen Epstein sits down with Shay Moraga, founder of Shay’s Warriors, to explore the rarely discussed reality of life after cancer.

Diagnosed with stage III triple-negative breast cancer at just 38, Shay shares how subtle symptoms were dismissed, how survivorship brought unexpected loneliness, and how that experience led her to create a community focused on healing beyond treatment. Together, Amy and Shay discuss fear of recurrence, identity after illness, accountability, and why collaboration is essential in women’s health and cancer advocacy.

Grief doesn’t end when someone dies—it evolves, deepens, and sometimes transforms into purpose. In this episode of The SEAM Podcast, Amy Cohen Epstein sits down with Emmy-winning actress, producer, and podcast host Nikki Boyer on the eve of her 50th birthday to reflect on friendship, caregiving, and what it means to carry someone you love forward after loss. Nikki opens up about her relationship with her best friend Molly—whose story became the groundbreaking podcast and FX series Dying for Sex—and the ways grief, legacy, and love continue to shape her life, marriage, and sense of meaning.

Most of us think of aging as just a biological clock. But what if it’s not just about how many birthdays we’ve celebrated? What if the real driver is how often our cells are forced into “danger mode”? This is the premise of emerging science around something called the Cell Danger Response (CDR). It’s a mouthful, but the idea is pretty simple. When your cells sense threat (whether it’s from toxins, infections, chronic stress, or poor diet) they flip a switch and enter protective mode….

In this episode of The SEAM Podcast, Amy Cohen Epstein sits down with Annbeth Eschbach, a pioneering women’s longevity specialist and founder of Reset One, to unpack what longevity really means for women today. Moving beyond buzzwords and biohacking hype, Annbeth shares her thoughts on how to shift from reactive healthcare to proactive health-span optimization, the realities of perimenopause and hormone care, why muscle is a critical longevity organ, and how women can reclaim agency over their health through data-driven, physician-led care.

Reproductive health is rarely discussed early enough—or holistically enough— for women facing cancer. In this episode of The SEAM Podcast, host Amy Cohen Epstein sits down with Dr. Roohi Jeelani, a double board-certified Reproductive Endocrinologist and Infertility Specialist, to unpack what doctors know—but patients are rarely told—about fertility preservation, oncofertility, longevity medicine, and women’s reproductive health across the lifespan.