Resetting Longevity: Annbeth Eschbach Decodes the Future of Wellness After Cancer, Precision Medicine, and Healthspan

In this episode of The SEAM Podcast, Amy Cohen Epstein sits down with Annbeth Eschbach, a pioneering women’s longevity specialist and founder of Reset One, to unpack what longevity really means for women today. Moving beyond buzzwords and biohacking hype, Annbeth shares her thoughts on how to shift from reactive healthcare to proactive health-span optimization, the realities of perimenopause and hormone care, why muscle is a critical longevity organ, and how women can reclaim agency over their health through data-driven, physician-led care.

Amy Cohen Epstein: I’m here this afternoon with Annbeth Eschbach, and we’re going to talk about a lot of exciting things — especially longevity, which is very much the hot topic right now. You’re a true builder, soup to nuts. You take ideas from vision to scale. I want you to walk us through how you got here, the companies you’ve built, and what brought you into longevity medicine.

Annbeth Eschbach: I think I am fundamentally a builder. Everything I’ve done has been taking something from vapor and vision to scale. And what led me here is honestly everything — personally and professionally. I grew up watching my father, a pioneering nephrologist, conduct groundbreaking research that led to Epogen. All he cared about was improving patients’ lives.

I then spent 35 years building transformational wellbeing and health brands. I founded Exhale and scaled it to 30 locations before selling to Hyatt. We embedded mind-body transformation into every experience. Later, I helped build Kindbody in the fertility space, making care more accessible and affordable. But today, the next frontier is consumer health — and it’s happening now.

Instead of reactive, one-size-fits-all healthcare, we finally have the science and data to deliver proactive, precision-based care. We can combine advanced medical treatments with lifestyle interventions to create outsized outcomes. And the most exciting part? We can finish the next decade biologically healthier than we are today.

Amy Cohen Epstein: That idea of “vapor and vision” is so vivid. You’ve always stayed true to your core mission — never compromising integrity. That’s brand longevity. But hasn’t wellbeing always been the common thread?

Annbeth Eschbach: Yes — but this is different. This is not wellbeing 1.0. With Reset One, we integrate sleep, nutrition, movement, and lifestyle with peptides, hormones, and advanced therapeutics. Genes are only part of the picture — epigenetics and lifestyle matter enormously. When you personalize care at the individual level, that’s where the transformation happens.

Amy Cohen Epstein: That integrity also applies to our bodies — listening to them instead of ignoring signals.

Annbeth Eschbach: Exactly. Historically, women were told what to do by doctors. Now, there’s a shift toward partnership and self-advocacy. Longevity medicine has to be physician-led, evidence-based, and credible — especially in a space that can easily drift into hype.

Amy Cohen Epstein: Let’s break it down. When people hear “longevity,” they imagine living to 120. What does it actually mean?

Annbeth Eschbach: We focus on healthspan, not lifespan. It’s about quality of life — energy, cognition, mobility, sleep — and preventing disease. Longevity is essentially preventive health rebranded in a more actionable, precise way. And unlike old preventive models, we can see results in weeks, not decades.

Amy Cohen Epstein: Which is why insurers haven’t caught up yet.

Annbeth Eschbach: Exactly. But the data is coming. We’ve already seen dramatic improvements in biological age, biomarkers, and — most importantly — quality of life. Our patients say, “Stop talking about weight loss. My life has changed.”

Amy Cohen Epstein: That’s the hardest thing to quantify — but the most important.

Annbeth Eschbach: We did quantify it. Across domains like sleep, energy, cognition, stress, and confidence, we saw 66–75% improvement in seven months. I’ve lived it myself — better sleep, grounded energy, sharper cognition. It’s profound.

Amy Cohen Epstein: Hormones are a huge piece of this, especially for women in perimenopause.

Annbeth Eschbach: Absolutely. So many women are put back on the pill instead of receiving proper bioidentical hormone therapy. If we intervened earlier, we’d avoid so much unnecessary suffering. Muscle, too, is a longevity organ — strength training is critical. And wearables allow us to gamify health, making progress visible and motivating.

Amy Cohen Epstein: And this isn’t just for older people.

Annbeth Eschbach: Not at all. Our fastest-growing cohort is in their 30s. They’re informed, proactive, and investing early. We’re going to see much healthier generations because of it.

Amy Cohen Epstein: This is such a powerful reframing — longevity as dignity, agency, and quality of life.

Annbeth Eschbach: And community. Social connection is a major longevity factor. This isn’t just about medicine — it’s about how we live.

Amy Cohen Epstein: Thank you for this. It’s rare to see science, integrity, and humanity aligned so clearly.

Annbeth Eschbach: Thank you. I’m honored to be part of this conversation.

Editor’s Note: This interview has been edited for length, clarity, and readability.